Contracting vampirism in The Elder Scrolls IV: Oblivion transforms your character's combat capabilities while imposing severe daylight penalties and social drawbacks. Players looking to reverse this condition can choose between immediate early treatment options or completing an involved storyline quest. Understanding each available method ensures you can quickly recover your normal status and explore Cyrodiil without relying on blood feeding.

Early Treatment for Porphyric Hemophilia

Before full transformation occurs, the affliction begins as a basic infection known as Porphyric Hemophilia. During this initial 72-hour window, you can easily remove the infection before resting triggers permanent vampirism.

Drinking a standard Cure Disease potion or praying at any chapel altar will clear the affliction instantly. Casting a Restoration spell with Cure Disease effects or eating specific ingredients like mandrake root also prevents full transformation.

Using Deepscorn Hollow and the Font of Renewal

If you have access to official add-on content, the fastest cure after full transformation lies within Deepscorn Hollow. Situated in Topal Bay, this subterranean lair houses a unique stone shrine called the Font of Renewal.

To activate the fountain, players must harvest Purgeblood Salts from a nearby mineral formation inside the cave. Interacting with the Font of Renewal while carrying these salts instantly purges vampirism without requiring lengthy ingredient gathering.

Starting the Official Vampire Cure Quest

Players relying on the base game must speak with Raminus Polus at the Arcane University in the Imperial City to initiate the Vampire Cure quest. He redirects you to Count Janus Hassildor of Skingrad, who seeks a cure for his afflicted wife.

The Count points players toward a witch named Melisande located in her secluded hut near Drakelowe. Speaking with Melisande begins a demanding scavenger hunt that requires specific alchemy materials and rare soul gems.

Gathering Ingredients for Melisande

Melisande first requires five empty Grand Soul Gems, which can be acquired from various Mages Guild merchants across Cyrodiil. Next, you must gather two shoots of bloodgrass, five nightshade leaves, and six cloves of garlic.

Finally, players must collect dust from the vampire Hindaril in Redwater Slough and obtain blood from an Argonian using a special dagger. Delivering these items to Melisande yields a cure potion that restores your original mortal state permanently.